For structural biologists who study proteins, predicting their shape offers a key to understanding their function and accelerating treatments for diseases like cancer and COVID-19. The current approaches to accurately mapping that shape have their limitations, but by applying powerful machine learning methods to the large library of protein structures it is now possible to predict a protein’s shape from its gene sequence.
Christiansen to Assume Interim Area Deputy Role
Paul Adams, Director of the Molecular Biophysics and Integrated Bioimaging Division, has announced that Katy Christiansen will assume the role of Interim Area Deputy while he is serving as Associate Laboratory Director (ALD) for the next year. Effective August 23, Christiansen will work with Adams to support the Area’s scientific mission and be responsible for helping to plan and execute the long-range strategy of the Biosciences Area.
Biosciences Area and Molecular Biophysics and Integrated Bioimaging Division Leadership Changes
Mary Maxon, Associate Laboratory Director (ALD) for Biosciences, has been granted a one-year leave of absence to help advance science and technology opportunities for engineering biology and the U.S. bioeconomy. Beginning August 23, Maxon will work on temporary assignment with Schmidt Futures, a philanthropic initiative founded by Eric and Wendy Schmidt, as they launch a significant effort to seed the next wave of engineering biology and bioeconomy innovation.
Paul Adams, Director of the Molecular Biophysics and Integrated Bioimaging (MBIB) Division, has been asked by Lab Director Mike Witherell to serve as the ALD for Biosciences over the coming year. While Adams is serving as Biosciences ALD, MBIB Deputy for Science Junko Yano will take on the role of Interim MBIB Division Director; Greg Hura has agreed to step into the role of Interim MBIB Science Deputy; and Susan Tsutakawa will be the Interim Head of the Structural Biology Department for the coming year.
Q&A: Molecular Imaging Behind COVID-19 Breakthroughs
A team led by Paul Adams, director of Berkeley Lab’s Molecular Biophysics and Integrated Bioimaging Division, developed the Phenix software suite, now used around the world to automate key steps in the structural biology workflow. Adams spoke with the Strategic Communications about the software’s origins and how structural biologists leapt into action to combat the pandemic.
New Algorithm Sharpens Focus of World’s Most Powerful Microscopes
In recent years, cryo-electron microscopy (cryo-EM) technology has advanced to the point that it can produce structures with atomic-level resolution for many types of molecules. Yet in some situations, even the most sophisticated cryo-EM methods still generate maps with lower resolution and greater uncertainty than required to tease out the details of complex chemical reactions.
In a study published in Nature Methods, a multi-institutional team led by Tom Terwilliger from the New Mexico Consortium and including researchers from Berkeley Lab demonstrates how a new computer algorithm improves the quality of the 3D molecular structure maps generated with cryo-EM.
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