A Berkeley Lab team analyzed the genotypes and phenotypes of several Arthrobacter strains to correlate cellular functions to their location at varying depths within a single sediment core and in nearby groundwater. They found that Arthrobacter, as a genus, has remarkable flexibility in altering its suites of carbon degradation genes. This genomic variation was found to be linked to the individual strain’s environment and is the basis for Arthrobacter’s ability to break down a wide variety of complex carbon sources.
A new digital brochure released by Berkeley Lab showcases a suite of biological research software developed in large part by Biosciences Area scientists. In collaboration with the Lab’s Computational Research Division, the National Energy Research Scientific Computing Center (NERSC), and other DOE national labs and academic institutions, scientists created 16 open- and closed-source software and tools in their part to accelerate progress across biological research. Ranging from imaging to omics research to synthetic biology tools, there’s something for everyone.
A team of scientists, including many in the Molecular Biophysics and Integrated Bioimaging Division, uncovered new details about the reaction that powers photosynthesis. Understanding this reaction could lead to world-changing advances in technology, medicine, or energy––and also gives insight into how the enzyme photosystem II produces the oxygen we breathe. Their latest work was recently published in Nature Communications and two of the authors, Vittal Yachandra and Philipp Simon, spoke with Strategic Communications about that, shooting stuff with lasers, and why they chose this field of research.
Researchers from the Baylor College of Medicine employed previously constructed DNA-encoded chemistry technology (DEC-tec) libraries to identify several candidate molecules that could inhibit the action of Mpro, the main protease of SARS-CoV-2. In a recent study, the researchers described CDD-1713, a new inhibitor to the enzyme Mpro that is involved in propagating the virus. The X-ray crystallographic data, which was collected by Banumathi Sankaran in the Molecular Biophysics and Integrated Bioimaging Division, allowed the researchers to determine that CDD-1713 inhibits the activity of Mpro by binding in the active site of this enzyme.
On October 28, Berkeley Lab marked the groundbreaking for the Biological & Environmental Program Integration Center (BioEPIC), a next-generation facility for studying interactions among microbes, water, soil, and plants. The groundbreaking ceremony at the Bayview site included members of Berkeley Lab leadership, science groups involved with BioEPIC, site cleanup and construction groups, and the construction contractor.