Researchers at the Baylor College of Medicine identified a small-molecule protein inhibitor that blocks an enzyme that is key to male fertility. Protein crystallography performed at the Advanced Light Source (ALS) beamline 5.0.2 provided valuable structure-activity insights.
Caught in the Actinium
Berkeley Center for Structural Biology beamline scientists contributed their expertise to a structural study of the radioactive metal actinium led by the Chemical Sciences Division’s Rebecca Abergel.
Researchers Gain Mechanistic Insight into a Viral-factory Protein
A team that included Banumathi Sankaran of the Molecular Biophysics and Integrated Bioimaging Division studied a protein called σNS, an important component of some viral factories. Understanding how this protein works will foster development of therapeutic strategies against viruses that use similar proteins to replicate.
Gemini Beamline Banks First Protein Structure
A protein structure obtained at Beamline 2.0.1 (“Gemini”) at the Advanced Light Source (ALS) has recently been published in the literature and deposited into the Protein Data Bank—two significant firsts for this beamline. The structure helped provide new insights into the molecular mechanisms involved in triggering certain inflammatory diseases. This milestone, which utilized Gemini’s capacity to target crystals smaller than 20 microns, was almost a decade in the making. Simon Morton, now a semi-retired staff scientist at ALS, and Corie Ralston, facility director at the Molecular Foundry and a staff scientist in the Molecular Biophysics and Integrated Bioimaging Division (MBIB), helped bring the microfocus beamline to the Berkeley Center for Structural Biology (BCSB) in 2014. Beamline operations are now led by Marc Allaire, a biophysicist staff scientist in MBIB and head of the BCSB.
Read More in the Berkeley Lab News Center.
Anthony Rozales, Beamline Runner
For Anthony Rozales, his shift overseeing the protein crystallography beamlines begins before the sun rises. While some might find the early mornings grueling, for him it’s ideal. Most days, after his shift ends and he makes it home, Rozales usually turns right around and leaves again, this time on foot.
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