Paul Yaswen of the Environmental Genomics & Systems Biology Division was part of a team of researchers from Berkeley Lab, UCSF, and the Buck Institute who co-authored an October 24 Nature Medicine publication on their research that showed the potential of PIM1 kinase inhibition for treatment of patients with triple-negative breast cancer (TNBC). TNBC, which lacks the expression of the estrogen, progesterone, and HER2 receptors, represents the breast cancer subtype with the poorest outcome. No targeted therapy is available against this subtype due to lack of validated molecular targets.
Several Biosciences Area personnel have been named as recipients of 2016 Berkeley Lab Director’s Awards. Yan Liang (Biological Systems & Engineering), Eva Nogales, and William Jagust (Molecular Biophysics & Integrated Bioimaging, MBIB) were honored with individual awards in Early Career, Scientific Achievement, and Societal Impact, respectively. Jill Fuss and Steven Yannone (MBIB) were the recipients of a team award in Technology Transfer for the launch of their company CinderBio. Jim Bristow (Biosciences Area Office, Trent Northen (Environmental Genomics & Systems Biology & Joint Genome Institute, JGI), and Susannah Tringe (JGI), along with Eoin Brodie and Peter Nico of the Earth and Environmental Sciences Area, were named in a team award in Service.
Researchers have shown that when parts of a genome known as enhancers are missing, the heart works abnormally, a finding that bolsters the importance of DNA segments once considered “junk” because they do not code for specific proteins. The study, led by Environmental Genomics & Systems Biology (EGSB) Division scientists Diane Dickel, Axel Visel and Len Pennacchio, appears in the journal Nature Communications. The team included other members of EGSB’s Mammalian Functional Genomics Laboratory and collaborators from the Ludwig Institute for Cancer Research and UC San Diego.
The Biosciences Area is pleased to announce that Adam Deutschbauer and Diane Dickel have agreed to take on new leadership positions in the Environmental Genomics & Systems Biology (EGSB) Division. Deutschbauer, previously the department head of Functional Genomics, is rising to the position of EGSB co-deputy for science, and Dickel will assume the role of … Read more »
A new study, led by Gary Karpen of the Biological Systems & Engineering (BSE) Division, links the overexpression of 14 genes related to cell division to cancer patients’ prognosis and response to specific treatments. The researchers said the findings, published today in the journal Nature Communications, could lead to a new biomarker for the early stages of tumor development. The information obtained could help reduce the use of cancer treatments that have a low probability of helping.
The research team included lead author Weiguo Zhang and Jian-Hua Mao of BSE; collaborators Wei zhu and Anshu Jain; and Ke Liu and James (Ben) Brown of the Environmental Genomics & Systems Biology Division. Read more on the Berkeley Lab News Center.