Two scientists in the Area, Greg Hura and Vivek Mutalik, are heading up research projects that are part of the Department of Energy’s Biopreparedness Research Virtual Environment (BRaVE) initiative. Yasuo Yoshikuni, a scientist at the Joint Genome Institute, is part of a third project that is being led by Brookhaven National Laboratory. These projects will leverage bioimaging expertise to develop better therapies and vaccines for viruses, develop a high-throughput platform to rapidly design countermeasures to drug-resistant pathogens, and unlock the molecular basis of plant-pathogen interactions to create resilient bioenergy crops.
Researchers Aid in Quest to Identify Genetically Engineered Organisms
The scientific and national security communities have long shared an unmet need for a tool capable of quickly and reliably distinguishing genetically modified organisms from naturally occurring ones. Over the course of a six-year program funded by the United States Intelligence Advanced Research Projects Activity (IARPA), several techniques were developed and refined. Biosciences Area researchers led testing and evaluation of these technologies, designing and producing biological samples of increasing complexity to assess how well the tools performed.
A Roadmap for Gene Regulation in Plants
A team of researchers from the Joint BioEnergy Institute’s (JBEI) Feedstocks Division has, for the first time, developed a genome-scale way to map the regulatory role of transcription factors, the proteins that play a key role in gene expression and determining a plant’s physiological traits. Their work reveals unprecedented insights into gene regulatory networks and identifies a new library of DNA parts that can be used to optimize genetic engineering efforts in plants.
Dylan Chivian, Microbial Explorer
Dylan Chivian’s upbringing motivated him to help humanity and the natural world. Now a microbial scientist and coding engineer with the Department of Energy Systems Biology Knowledgebase (KBase), he’s building software tools that aim to share microbial genomic information and promote collaboration across the broader scientific community.
Dub-seq Used to Screen Phage Proteins for Antibiotic Properties
As conventional antibiotics continue to lose effectiveness against evolving pathogens, scientists are keen to employ the bacteria-killing techniques perfected by bacteriophages (phages), the viruses that infect bacteria. One major challenge is the difficulty of studying individual phage proteins and determining precisely how the virus wields these tools to kill their host bacteria. A team of researchers from Berkeley Lab, UC Berkeley, and Texas A&M University worked together on a high-throughput genetic screen to identify which part of the bacteria the phages were targeting.
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