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Two reconstructions of imaging: one soft x-ray tomographic reconstruction showing misfolded proteins in the cytoplasm being engulfed by vacuoles, the cell’s protein degradation machinery, and one super-resolution, visible-light microscopy reconstruction showing misfolded proteins being extruded from the nucleus toward a vacuole through a nuclear-vacuolar junction. Soft X-ray tomography provides a map of organelles within an intact cell. (Credit: Katya Kadyshevskaya/USC) DNA, HU and chromatin images

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