A recent Berkeley Lab News Center roundup of “Five Ways LiSA is Advancing Solar Fuels,” included a project led by Molecular Biophysics and Integrated Bioimaging Division Director Junko Yano that could enable characterization, under real-world conditions, of the chemical reactions that take place where a metal catalyst and electrolyte meet.
A Better Understanding of DNA Unpacking
Using specialized equipment, including high-resolution cryo-EM researchers were able to study the atomic structure of a complex that allows enzymes to access DNA.
Time-Resolved SAXS Screen of Small-Molecule Drug Candidates
A team of researchers developed a high-throughput drug-discovery workflow leveraging time-resolved small-angle x-ray scattering (SAXS) capabilities at the Advanced Light Source’s (ALS) Structurally Integrated Biology for the Life Sciences (SIBYLS) beamline to identify small molecules capable of activating biomolecular dynamics associated with a desired therapeutic outcome.
Structural Biology Brings Chemotherapy Resistance Into High Resolution
Biosciences researchers conducted the first ever structural analysis of a key protein involved in DNA damage repair and cancer. While the narrative around cancer chemotherapy has historically focused on DNA damage repair pathways, findings from this study underscore the role of RNA-mediated processes on chemotherapy response, which could have major implications for cancer treatment outcomes.
Caught in the Actinium
Berkeley Center for Structural Biology beamline scientists contributed their expertise to a structural study of the radioactive metal actinium led by the Chemical Sciences Division’s Rebecca Abergel.
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