The biopolymer has far-reaching potential from medical therapeutics to replacing synthetic plastics. Armed with a deep understanding of how the enzymes makes acholetin, scientists now have a target for preventing bacterial contamination and the means to produce acholetin for a variety of purposes.
Designing Cyclic Oligomers: Greater than the Sum of Their Parts
Cyclic proteins that assemble from multiple identical subunits (homo-oligomers) play key roles in many biological processes, including enzymatic catalysis and function and cell signaling. Researchers in the Molecular Biophysics and Integrated Bioimaging (MBIB) Division worked with University of Washington’s David Baker, who led a team to design in silico and crystallize self-assembling cyclic homo-oligomer proteins.
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