Researchers in the Biological Systems and Engineering (BSE) Division are collaborating with colleagues at the Berkeley Lab Laser Accelerator (BELLA) Center to adapt the nascent technology of laser-driven ion accelerators to make a more effective type of radiation more readily available to patients. The mutually beneficial partnership gives BELLA scientists a real-world application around which to refine their experimental laser platform, and gives the biologists a chance to test how living tissue responds to laser-driven proton beams at FLASH dose rates.
Berkeley Lab thirdhand smoke researchers have been awarded a new three-year grant totaling $904,744. The funding from the Tobacco-Related Disease Research Program (TRDRP) will support translational studies aimed at mitigating health impacts of exposure to thirdhand smoke (THS)—the toxic residues from tobacco smoke that linger on indoor surfaces and in dust long after a cigarette has been extinguished. From the Biosciences Area, Biological Systems and Engineering (BSE) Division staff scientist Bo Hang will serve as principal investigator on the studies, with senior scientist Jian-Hua Mao and staff scientist Antoine Snijders, also of BSE, as co-investigators. Collaborators on the project include staff scientist Hugo Destaillats and retiree affiliate Lara Gundel in the Energy Technologies Area (ETA) at Berkeley Lab, as well as researchers at California Consortium on Thirdhand Smoke partner institutions UC San Francisco and UC Riverside.
An international team led by researchers in Berkeley Lab’s Biosciences Area has identified a new laboratory mouse strain for studying gastric cancer. The mouse lineage is part of a population called the Collaborative Cross (CC) mouse model that was bred to have greater genetic diversity than previous populations, so as to be more comparable with humans. The team monitored hundreds of mice from different CC strains for one year and observed that one line spontaneously developed tumors—stomach and lymphoid being the most prevalent types—at an extremely high rate. Subsequent genetic analysis of the tumors in this cancer-prone line revealed that an inflammatory response regulating a protein called Nfκb1 could be a key driver of cancer susceptibility in this mouse model.
Read more in the Berkeley Lab News Center.
When studying human cells in a laboratory, it is important that the media, or the broth that bathes the cells, contains all of the nutrients necessary to support cells through their normal growth and division phases even though they are outside of the body. Bioscientists at Berkeley Lab have a long history of studying breast cancer, and Martha Stampfer, senior scientist in the Biological Systems & Engineering (BSE) Division, has spent decades developing media now widely used by the community. Today, PLOS ONE published a study describing a comprehensive analysis of three kinds of media used to grow human mammary epithelial cells (HMEC).
Cigarette smoke contains myriad compounds that are known mutagens and carcinogens, and the health risks associated with active smoking and secondhand smoke are well established. Nearly 10 years ago, researchers at Berkeley Lab identified another potentially hazardous source of tobacco exposure: “thirdhand smoke,” the toxic residues that linger on indoor surfaces and in dust long after a cigarette has been extinguished. A team led by Antoine Snijders, Jian-Hua Mao, and Bo Hang in Biosciences’ Biological Systems and Engineering (BSE) Division have determined that early thirdhand smoke exposure is also associated with increased incidence and severity of lung cancer in mice.