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gray coiled representation of a protein structure with a small ribbon of green on the right side An overhead photo of a complex X-ray setup. Two reconstructions of imaging: one soft x-ray tomographic reconstruction showing misfolded proteins in the cytoplasm being engulfed by vacuoles, the cell’s protein degradation machinery, and one super-resolution, visible-light microscopy reconstruction showing misfolded proteins being extruded from the nucleus toward a vacuole through a nuclear-vacuolar junction. Colorful illustration of spherical lipid nanoparticles. Digital illustration of coiled molecules assembled into larger constructs. Ribbon diagram of a protein structure.

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