The Berkeley Lab community mourns the loss of Stephen R. Holbrook, who died August 12 at age 68. Holbrook joined the Lab in 1979 as a staff scientist in the Laboratory of Chemical Biodynamics working with Prof. Sung-Hou Kim. He later led his own group in the Physical Biosciences Division, and was an affiliate in the Biosciences Area’s Environmental Genomics & Systems Biology (EGSB) Division. Holbrook’s research interests included the study of nucleic acid crystal structures, protein structures, prediction of novel RNAs, and prediction of protein complexes.