Biosciences Area

  • About Biosciences
    • Leadership
    • Area Operations Centers
    • Strategic Plan and Reports
    • Strategic Programs Development Group
    • Contact Information
  • Our Science
    • Area Programs
    • Strategic Initiatives
    • Biological Systems and Engineering
    • Environmental Genomics and Systems Biology
    • Molecular Biophysics and Integrated Bioimaging
    • DOE Joint Genome Institute
  • Media and Events
    • News
    • Announcements
    • Behind the Breakthroughs
    • Events Calendar
    • Seminar Series
  • Staff Resources
    • Commonly Used Acronyms
    • Communications
    • Hiring and Recruitment
    • Hybrid & Telework Resources
    • IDEA
    • Intellectual Property, Industry Engagement, and Entrepreneurship
    • LDRD Information
    • Logos and Templates
    • Mentoring Program
  • Search

Out for Blood: New Model Shows Promise for Personalized, Precision Transfusions for Trauma Patients

January 9, 2017

After trauma injury, some patients develop acute traumatic coagulopathy (ATC), a biological response with increased bleeding, morbidity and mortality. This condition is difficult to diagnose in real-time because relevant laboratory tests take hours and the coagulation mechanisms following injury are not well understood, creating further problems when patients are transfused with massive amounts of untargeted blood products. Mortality is 40 to 70% in the best trauma centers. Current models are unsuited for trauma coagulation or take days to run.

Amor Menezes and Adam Arkin of the Environmental Genomics & Systems Biology Division collaborated with clinicians to develop a simple, fast trauma coagulation model using control theory, published this week in Science Translational Medicine, which can personalize the treatment of severely injured patients with ATC from only laboratory measurements that take a few minutes. Using this model, the authors accurately predicted an hour-long laboratory test, calculated patient-specific transfusion requirements, and demonstrated in vitro that a driver of coagulation in these patients could be controlled as calculated. This ability to quickly predict and leverage accurate individualized information could be key to future treatment of patients with ATC.

Was this page useful?

Send
like not like

About Biosciences

  • Leadership
  • Area Operations Centers
  • Inclusion, Diversity, Equity, and Accountability (IDEA)
  • Contact

Divisions & User Facility

  • Biological Systems and Engineering
  • Environmental Genomics and Systems Biology
  • Molecular Biophysics and Integrated Bioimaging
  • DOE Joint Genome Institute

Resources

  • A-Z Index
  • Phonebook
  • Logos
  • Acronyms
  • Integrated Safety Management
Questions & Comments
Follow us: Mastodon LinkedIn YouTube