Research Interests

Our group maintains a long-standing interest in the structure and function of macromolecular complexes, with an emphasis on membrane protein biology. Areas of investigation have included molecular mechanisms facilitating solute transport, intra-membrane proteolysis, cell-cell interactions, protein-protein interaction networks, and cellular responses to stress. Proteins in these studies have been characterized using a range of biophysical and biochemical approaches involving methods such as the large-scale purification of recombinant and endogenously expressed proteins, liposome reconstitution, electron microscopy, X-ray and electron crystallography, molecular dynamics simulations and proteomics.

Selected Publications