Biosciences Area

  • About Biosciences
    • Leadership
    • Area Operations Centers
    • Strategic Plan and Reports
    • Strategic Programs Development Group
    • Contact Information
  • Our Science
    • Area Programs
    • Strategic Initiatives
    • Biological Systems and Engineering
    • Environmental Genomics and Systems Biology
    • Molecular Biophysics and Integrated Bioimaging
    • DOE Joint Genome Institute
  • Media and Events
    • News
    • Announcements
    • Behind the Breakthroughs
    • Events Calendar
    • Seminar Series
  • Staff Resources
    • Commonly Used Acronyms
    • Communications
    • Hiring and Recruitment
    • Hybrid & Telework Resources
    • IDEA
    • Intellectual Property, Industry Engagement, and Entrepreneurship
    • LDRD Information
    • Logos and Templates
    • Mentoring Program
  • Search

Researchers ID New Mechanism for Keeping DNA Protein in Line

July 5, 2017

FEN1, an enzyme involved in DNA replication and repairUsing a combination of crystallographic, biochemical, and genetic analyses, Berkeley Lab researchers have shown that the actions of FEN1, an enzyme involved in DNA replication and repair, are guided by electrostatic forces known as phosphate steering. Susan Tsutakawa and John Tainer in the Biosciences Area’s Molecular Biophysics and Integrated Bioimaging (MBIB) Division were the lead and corresponding authors, respectively, on the report published this week in Nature Communications. The work reveals key details of this previously unknown mechanism controlling the specificity of FEN1 in healthy cells and provides new directions for cancer treatment research. Read more from the Berkeley Lab News Center.

Was this page useful?

Send
like not like

About Biosciences

  • Leadership
  • Area Operations Centers
  • Inclusion, Diversity, Equity, and Accountability (IDEA)
  • Contact

Divisions & User Facility

  • Biological Systems and Engineering
  • Environmental Genomics and Systems Biology
  • Molecular Biophysics and Integrated Bioimaging
  • DOE Joint Genome Institute

Resources

  • A-Z Index
  • Phonebook
  • Logos
  • Acronyms
  • Integrated Safety Management
Questions & Comments
Follow us: Mastodon LinkedIn YouTube