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LBNL logo Colorful 3D-image of a spiral protein structure, with blurring to indicate that the structure moves between two conformational shapes. Two reconstructions of imaging: one soft x-ray tomographic reconstruction showing misfolded proteins in the cytoplasm being engulfed by vacuoles, the cell’s protein degradation machinery, and one super-resolution, visible-light microscopy reconstruction showing misfolded proteins being extruded from the nucleus toward a vacuole through a nuclear-vacuolar junction. Colorful illustration of spherical lipid nanoparticles. Researchers pose next to lab equipment.

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