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Colorful 3D-image of a spiral protein structure, with blurring to indicate that the structure moves between two conformational shapes. Two reconstructions of imaging: one soft x-ray tomographic reconstruction showing misfolded proteins in the cytoplasm being engulfed by vacuoles, the cell’s protein degradation machinery, and one super-resolution, visible-light microscopy reconstruction showing misfolded proteins being extruded from the nucleus toward a vacuole through a nuclear-vacuolar junction. Colorful illustration of spherical lipid nanoparticles. Researchers pose next to lab equipment. Digital illustration of coiled molecules assembled into larger constructs. Black and white photo of two men, Melvin Klein and Kenneth Sauer, working together behind a computer. Using SLAC’s X-ray laser, researchers have finally seen the process by which nature creates the oxygen we breathe. (Credit: Greg Stewart/SLAC National Accelerator Laboratory)

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