Berkeley Lab researchers uncovered a distinctive adaptation that some bacteria use to quickly form protective communities called biofilms, which help them survive in adverse environments. The work could lead to better stewardship of areas with high levels of heavy metals, nutrients, or other forms of hazardous waste.
A Promising Compound for Reversible Male Contraception
Researchers at the Baylor College of Medicine identified a small-molecule protein inhibitor that blocks an enzyme that is key to male fertility. Protein crystallography performed at the Advanced Light Source (ALS) beamline 5.0.2 provided valuable structure-activity insights.
Paving the Way for a Solar Fuels Future
A recent Berkeley Lab News Center roundup of “Five Ways LiSA is Advancing Solar Fuels,” included a project led by Molecular Biophysics and Integrated Bioimaging Division Director Junko Yano that could enable characterization, under real-world conditions, of the chemical reactions that take place where a metal catalyst and electrolyte meet.
A Better Understanding of DNA Unpacking
Using specialized equipment, including high-resolution cryo-EM researchers were able to study the atomic structure of a complex that allows enzymes to access DNA.
Time-Resolved SAXS Screen of Small-Molecule Drug Candidates
A team of researchers developed a high-throughput drug-discovery workflow leveraging time-resolved small-angle x-ray scattering (SAXS) capabilities at the Advanced Light Source’s (ALS) Structurally Integrated Biology for the Life Sciences (SIBYLS) beamline to identify small molecules capable of activating biomolecular dynamics associated with a desired therapeutic outcome.
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