Biosciences researchers Axel Visel (JGI/EGSB) and Marco Osterwalder (EGSB) contributed to a study, led by researchers at the Max Planck Institute for Molecular Genetics, in which targeted genome editing and a transgenic reporter assay were used to characterize elements regulating Ihh (encoding Indian hedgehog) in mice. Indian hedgehog is a mammalian signaling protein involved with the development and proliferation of cells in cartilage. In humans, copy number variants (CNVs) upstream of Ihh cause localized phenotypes including premature fusion of the sutures of the skull and malformation of the phalanges. The study, published in Nature Genetics, showed that in mice Ihh is regulated by modular ensembles of enhancers (with individual tissue specificities) that appear to act in an additive manner. Despite apparent redundancy and overlapping function of enhancers, these ensembles—in which the correct number of each enhancer is present—are necessary for precise spatiotemporal control of developmental gene expression.
Another Successful Year for Biotech Partners Interns at Biosciences Area
The Biosciences Area partnered once again with Biotech Partners to provide paid summer internships to high school students. This year six high school students worked side by side with Biosciences researchers across the Area’s laboratories. The mission of the non-profit Biotech Partners is to educate underserved youth in the Bay Area with personal, academic and professional development experiences that increase participation in higher education and access to fulfilling science careers.
Dub-seq Named a Finalist for R&D 100 Awards
A method for discovering gene function in microbes developed by Adam Arkin, Adam Deutschbauer, Vivek Mutalik, and Pavel Novichkov of the Environmental Genomics and Systems Biology division has been shortlisted for R&D Magazine’s 2017 R&D 100 Award. The technology, called Dual Barcoded Shotgun Expression Library Sequencing (Dub-seq), combines the shotgun expression library method and next generation sequencing method developed through the ENIGMA program. Now in its 55th year, the prestigious R&D 100 Awards program recognizes the most innovative inventions of the prior year. The winners will be announced and honored at a black-tie ceremony to be held this fall in conjunction with the annual R&D 100 Conference.
Biosciences Researchers Brief Advisory Panel for Food and Agriculture
Two Joint BioEnergy Institute (JBEI) scientists recently joined colleagues from the Earth & Environmental Sciences Area to share their expertise with the California Department of Food and Agriculture’s Science Advisory Panel. They briefed the panel on their research related to enhancing plant-microbe interactions for improved plant yields and to increasing the efficiency of genome editing tool CRISPR in plants. Read more from Earth & Environmental Sciences.
Mortimer participates at WEF’s Annual Meeting of the New Champions
Jenny Mortimer, Deputy Vice President of the Feedstocks Division at the Joint BioEnergy Institute (JBEI) and Scientist with the Environmental Genomics and Systems Biology (EGSB) Division, participated at the World Economic Forum’s (WEF) 2017 Annual Meeting of the New Champions alongside business and political leaders. The annual meeting whose overall theme this year was inclusive growth in the fourth industrial revolution took place from June 27-29 in Dalian, China. At the meeting Mortimer participated at a press conference entitled “Young, talented and fighting for science” which can be viewed here.
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