A team of researchers developed a high-throughput drug-discovery workflow leveraging time-resolved small-angle x-ray scattering (SAXS) capabilities at the Advanced Light Source’s (ALS) Structurally Integrated Biology for the Life Sciences (SIBYLS) beamline to identify small molecules capable of activating biomolecular dynamics associated with a desired therapeutic outcome.
Researchers Gain Mechanistic Insight into a Viral-factory Protein
A team that included Banumathi Sankaran of the Molecular Biophysics and Integrated Bioimaging Division studied a protein called σNS, an important component of some viral factories. Understanding how this protein works will foster development of therapeutic strategies against viruses that use similar proteins to replicate.
BCSB Confirms AI-predicted Structure of Key Rotavirus Site
The effects of a stomach flu can range from pesky to deadly. Researchers recently used an AI program to predict the structure of a common rotavirus and collaborated with a Biosciences researcher working at the Advanced Light Source to validate their novel finding.
Study Expands Horizons for DNA Nanotechnology
Researchers at Arizona State University’s Biodesign Institute conducted the first systematic study of Holliday junctions—the nexus of two segments of double-stranded DNA—using crystallography techniques performed at the Advanced Light Source, the Argonne Photon Source, and the National Synchrotron Light Source II.
Enzyme Structure Reveals Key Details in Strigolactone Signaling
A recent study published in Nature Plants used a combination of genetic mutation and X-ray crystallography, conducted at the Berkeley Center for Structural Biology, to reveal structural details of a key enzyme involved in plant signaling.
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