EGSB News

N. Louise Glass, director of the Environmental Genomics & Systems Biology (EGSB) Division, announced new leadership as of October 1, 2018. Changes were implemented to diversify perspectives and ideas within the management of the Division. Ben Brown and Henrik Scheller have agreed to take on positions as Division co-deputies for science; Tanja Woyke and Chris Mungall will now serve as department heads of Functional Genomics and Molecular Ecosystems Biology, respectively.

Two teams of Biosciences Area researchers are representing Berkeley Lab as part of cohort eight of the U.S. Department of Energy’s I-Corps program, an intensive two-month training course that pairs national laboratory researchers with industry mentors to develop viable market pathways for their technologies. The teams, led by Deepti Tanjore and Esther Singer, presented their projects during the opening session held October 1–5 in Golden, Colorado.

By mining JGI’s massive database of microbial genomes and metagenomes, a team led by researchers at UC Berkeley and Berkeley Lab has identified a new family of CRISPR-associated (Cas) enzymes found in an ancient branch of the microbial tree of life. Just one-third the size of the seminal Cas9 protein – the business end of the gene-editing tool CRISPR-Cas9 – the new enzymes, dubbed Cas14, are the smallest functional CRISPR system discovered to date. Owing to its compact size and single-stranded DNA cutting activity, Cas14 may improve rapid CRISPR-based diagnostic systems now under development for infectious diseases, genetic mutations, and cancer.

A team of researchers led by Niren Murthy, a faculty scientist in the Environmental Genomics and Systems Biology (EGSB) Division, have created a test that can identify bacteria that are resistant to certain classes of antibiotics in a matter of minutes. The results of the test help doctors prescribe the right antibiotics for each infection and could help limit the spread of antibiotic-resistant ‘superbugs.’ These ‘superbugs’ actually contribute to about 700,000 deaths worldwide each year, but this new test increases patient’s chances of survival since the correct drug can be prescribed almost immediately.

Biosciences scientists Héctor García Martín, Jay Keasling, and Jill Banfield (whose primary affiliation is with the Earth & Environmental Sciences Area) were mentioned an article by Amia Srinivasan entitled “What Termites Can Teach Us” published in The New Yorker. Read the article.