Go team science! A new animation from the DOE JGI demonstrates how the DOE Joint Genome Institute, NERSC and Energy Sciences Network (ESnet) – all national user facilities at Berkeley Lab and supported by the U.S. Department of Energy Office of Science – work together, underpinning our critical research infrastructure to advance the frontiers of science, decode the Earth’s DNA, and improve our understanding of the world. Watch the video at bit.ly/UFvideoJGI on the DOE JGI Youtube channel.
JBEI Invention Leads to More Efficient Biofuel Production for Industrial Application
New Biosynthesis Pathways for Five-Carbon Alcohol from Mevalonate Are Available For Licensing
Researchers at the U.S. Department of Energy (DOE)’s Joint BioEnergy Institute (JBEI) have developed two novel biosynthesis pathways for five-carbon alcohol (isopentenol or 3-methyl-3-buten-1-ol) from mevalonate that reduce the energy demand and cost of earlier applications of the mevalonate pathway by using genetically engineered host cells, whose culturing stage can happen both in anaerobic or aerobic conditions. This invention can be used in an industrial scale, even under oxygen-limited conditions. These modified pathways would be a good platform for industrial production of isopentenol which is a potential gasoline alternative and a precursor of commodity chemicals such as isoprene. Read more on the JBEI website.
Improving Meningococcal Vaccines
Two recently licensed vaccines against bacterial meningitis contain a bacterial surface protein antigen known as Factor H binding protein (FHbp). The native form of this protein can have low thermal stability, which limits its potential use as an antigen in vaccines. After engineering a more stable Factor H binding protein antigen, scientists from UC San Francisco Benioff Children’s Hospital Oakland determined the structure of the stabilized vaccine with the help of protein crystallography at the Advanced Light Source (ALS) in the Berkeley Center for Structural Biology (Beamline 5.0.1). Read more in the ALS Science Brief.
Raising the Bar for Bacterial Interactions Networks
Scientists working as part of a multi-investigator ENIGMA (Ecosystems & Networks Integrated with Genes and Molecular Assemblies Scientific Focus Area) project have determined that protein-protein interactions occur more frequently among proteins with similar functions. The team of researchers, led by Gareth Butland in the Environmental Genomics & Systems Biology Division, used high throughput functional genomics to study the protein-protein interactome of the model sulfate reducing bacterium Desulfovibrio vulgaris Hildenborough. Their findings critically re-evaluate published bacterial interaction networks and establish benchmarks for high confidence protein interactomes. The manuscript can be found online at Molecular and Cellular Proteomics.
“The Tale of the Bacteria Farmer” with JBEI’s Sarah Richardson
JBEI’s Post-Doctoral Researcher Sarah Richardson (Biological Systems and Engineering Division) teamed up with Team Escamilla at Tumble to record a science podcast for children ages 8 – 12, created to be enjoyed by the entire family. In this podcast episode Richardson explains how she’s trying to convince bacteria to make the things we need, such as biofuels. To listen click here. To learn more about Sarah’s research area and her outreach work click here.
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