While advances in sequencing technologies have enabled researchers to access the genomes of thousands of microbes and make them publicly available, the task of assigning functions to the genes uncovered has lagged behind due to the limited capacity of functional analysis approaches. To help overcome this bottleneck, Berkeley Lab researchers, led by Adam Arkin and Adam Deutschbauer in Biosciences’ Environmental Genomics and Systems Biology (EGSB) Division and Matthew Blow at the DOE Joint Genome Institute (JGI), have developed a workflow that enables large-scale, genome-wide assays of gene importance across many conditions.
Tau-tally Microtubular: A Structural Model of Tau-Microtubule Interaction
Researchers at Berkeley Lab and UC Berkeley have combined cutting-edge cryo-electron microscopy (cryo-EM) with computational molecular modeling to produce a near atomic-resolution model of the interaction between microtubules—crucial components of eukaryotic cell ultrastructure—and microtubule-associated proteins called tau. The model provides insight into how tau stabilizes microtubules, and what makes it dissociate to form tau aggregates, or “tangles,” in some neurological diseases—including Alzheimer’s disease—generally referred to as tauopathies.
Keasling and JBEI Profiled in MIT Technology Review
Biosciences CSTO Jay Keasling and the Joint BioEnergy Institute (JBEI), which he oversees as CEO and Director of New Pathways and Metabolic Models, were profiled for the MIT Technology Review website. In the feature entitled “The Scientist Still Fighting for the Clean Fuel the World Forgot,” Keasling discusses the progress made in the quest for affordable advanced biofuels, and underscores the need for continued research.
Banfield Elected to the Royal Society
Jillian Banfield, faculty scientist in the Earth and Environmental Sciences Area with a secondary appointment in the Environmental Genomics and Systems Biology Division, has been elected as a Fellow to the Royal Society. She is among fifty scientists who were selected for this honor in recognition of their exceptional contributions to science. Banfield, who is also a professor at UC Berkeley, studies the structure, functioning and diversity of microbial communities in natural environments and the human microbiome. Read more in the Royal Society press release.
Biosciences Researchers Honored by the National Academy of Sciences
Three scientists affiliated with the Biosciences Area have been recognized by the National Academy of Sciences (NAS), one as the recipient of an NAS award and two as newly elected members. On Sunday, the NAS formally presented its 2018 NAS Award in Chemical Sciences to Jennifer Doudna, a faculty biochemist in the Molecular Biophysics and Integrated Bioimaging (MBIB) Division. Judith Campisi, a biochemist affiliated with Biological Systems and Engineering Division, Ehud “Udi” Isacoff, an MBIB faculty biologist, are among the group of 84 new members elected to the NAS.
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