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How to Edit the Genes of Nature’s Master Manipulators

December 5, 2022

CRISPR-Cas13 creates an evolutionary bottleneck by targeting the RNA of diverse phages, allowing for edited phages (orange) to be specifically enriched. (Credit: Davian Ho)

A team led by CRISPR pioneer Jennifer Doudna and her longtime collaborator Jill Banfield has developed a clever tool to edit the genomes of bacteria-infecting viruses called bacteriophages using a rare form of CRISPR. The ability to easily engineer custom-designed phages—which has long eluded the research community—could help researchers control microbiomes without antibiotics or harsh chemicals, and treat dangerous drug-resistant infections. A paper describing the work was recently published in Nature Microbiology.

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