After decades of effort, scientists have revealed atomic-scale details of the water splitting step of photosynthesis, the chemical process that generates the air we breathe. The latest work adds to our understanding of photosynthesis and will aid the development of fully renewable alternative energy sources.
Gemini Beamline Banks First Protein Structure
A protein structure obtained at Beamline 2.0.1 (“Gemini”) at the Advanced Light Source (ALS) has recently been published in the literature and deposited into the Protein Data Bank—two significant firsts for this beamline. The structure helped provide new insights into the molecular mechanisms involved in triggering certain inflammatory diseases. This milestone, which utilized Gemini’s capacity to target crystals smaller than 20 microns, was almost a decade in the making. Simon Morton, now a semi-retired staff scientist at ALS, and Corie Ralston, facility director at the Molecular Foundry and a staff scientist in the Molecular Biophysics and Integrated Bioimaging Division (MBIB), helped bring the microfocus beamline to the Berkeley Center for Structural Biology (BCSB) in 2014. Beamline operations are now led by Marc Allaire, a biophysicist staff scientist in MBIB and head of the BCSB.
Read More in the Berkeley Lab News Center.
Anthony Rozales, Beamline Runner
For Anthony Rozales, his shift overseeing the protein crystallography beamlines begins before the sun rises. While some might find the early mornings grueling, for him it’s ideal. Most days, after his shift ends and he makes it home, Rozales usually turns right around and leaves again, this time on foot.
AI Technology Designs Novel Functional Enzyme
Molecular Biophysics and Integrated Bioimaging (MBIB) Division faculty scientists James Fraser and James Holton were part of a team that demonstrated that a natural language processing AI can design novel proteins that function as well as naturally occurring ones. This advance could energize the 50-year-old field of protein engineering by speeding the development of new proteins that can be used for almost anything from therapeutics to degrading plastic.
Adams Appointed ALD for Biosciences
Berkeley Lab Director Mike Witherell has appointed Paul Adams to the position of Associate Lab Director (ALD) for Biosciences. Adams has been serving as the interim ALD for the Biosciences Area since 2021, taking over for Mary Maxon, who is now with Schmidt Futures. Over the past two decades, Adams has played an important role promoting Berkeley Lab’s leadership in structural biology nationally and internationally. As ALD, Adams will continue to advance the Area’s scientific vision and operations excellence while advancing IDEA principles and broadening outreach to institutions serving groups that are underrepresented in STEM.
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