Several groups from the ALS hosted a booth at the 67th Annual Meeting of the American Crystallographic Association in New Orleans at the end of May. Staff from the crystallography, small-angle X-ray scattering, and X-ray footprinting beamlines were present, and flyers for infrared and soft X-ray tomography beamlines were also available.
A Hollow Pyramid Unlocks Principles of Protein Architecture
Researchers at UCLA have designed a hollow, pyramid-shaped protein with a controllable cavity size that may aid the capture and release of smaller compounds. The tools used in this work, including small angle X-ray scattering techniques at the SIBYLS beamline in the Advanced Light Source (ALS), will help analyze and optimize designed-protein assemblies and understand their behavior in solution. Read more in the ALS Science Brief.
Green Alga Sequencing Could Advance Clean Energy, Bioproducts
Scientists have sequenced the genome of a green alga that has drawn commercial interest as a strong producer of quality lipids for biofuel production. The chromosome-assembly genome of Chromochloris zofingiensis provides a blueprint for new discoveries in sustainable biofuels, antioxidants, and other valuable bioproducts. The team was led by Kris Niyogi, faculty biologist in the Molecular Biophysics and Integrated Bioimaging Division and included researchers from UCLA and UCSF. The alga was imaged in the National Center for X-ray Tomography, located at the Advanced Light Source. Read the science short at the Berkeley Lab News Center.
Designing Cyclic Oligomers: Greater than the Sum of Their Parts
Cyclic proteins that assemble from multiple identical subunits (homo-oligomers) play key roles in many biological processes, including enzymatic catalysis and function and cell signaling. Researchers in the Molecular Biophysics and Integrated Bioimaging (MBIB) Division worked with University of Washington’s David Baker, who led a team to design in silico and crystallize self-assembling cyclic homo-oligomer proteins.
Biosciences Participates at East Bay STEM Career Awareness Day
Biosciences Area researchers and staff participated at the annual East Bay STEM Career Awareness Day on April 27, 2017, at Wareham Development’s Aquatic Park Center in West Berkeley, home to Biosciences Operations @ Berkeley and several Area research groups.
The event was led by Cal State University East Bay’s Institute for STEM Education in partnership with local businesses and organizations, and was aimed at providing insight into potential STEM careers and educational opportunities in the region. Three hundred high school students from Berkeley, Emeryville, Oakland and Richmond engaged in activities around this year’s theme:, “What problem(s) are you trying to solve?” Students had the opportunity to network with a variety of STEM professionals during tours, a working lunch and exhibitor tabling.
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