Aparajitha Srinivasan placed third and Ying Wang was awarded People’s Choice in the Berkeley Lab Research SLAM competition on September 22. Srinivasan, a postdoctoral researcher at the Joint BioEnergy Institute (JBEI) in the Biological Systems and Engineering (BSE) Division, detailed her research on utilizing computational modeling to select the best routes to creating aroma additives. The Environmental Genomics and Systems Biology (EGSB) Division’s Wang covered how to determine which microbes eat which carbon molecules.
JGI Helps Develop Computational Pipeline for RNA Virus Sequences
In the journal Cell, scientists from a team led by researchers at Tel Aviv University in Israel, the National Center for Biotechnology Information, and the DOE Joint Genome Institute (JGI) describe a computational pipeline that can specifically scan for RNA virus sequences.
Bioscientists to Receive DOE Funding for Biomanufacturing and Microbiome Research
Biosciences researchers are among the recipients of four new DOE awards. Two awards will focus on reducing carbon emissions while producing bioenergy. The other two are aimed at understanding the role of microbiomes in the biogeochemical cycling of elements like carbon.
Berkeley Kauffman, Helix Surfer
A longtime fishing and surfing enthusiast, Berkeley Kauffman pursued his love for marine science in school and later embarked on a path in biochemistry. Now, Kauffman works on the JGI’s Micro-scale Applications group, helping their international users learn more about which microbial species are present and active in their environmental samples.
JGI Extracts the Secrets of Secondary Metabolites
Microbial secondary metabolites, those molecules not essential for growth yet essential for survival, may now be easier to characterize following a JGI proof-of-concept study in which researchers paired CRISPR and CRAGE technologies. CRAGE (developed by a JGI team led by Yasuo Yoshikuni) offers CRISPR a point of entry into microbes that it previously lacked. Then, by using CRISPR to knock out or activate genes, researchers at the JGI were able to monitor loss- and gain-of-function, with the analytical data showing peaks and valleys in secondary metabolites as genes are edited. The pairing proved to rapidly confirm enhanced production of 22 metabolites from six biosynthetic gene clusters. One of those was a metabolite from a previously uncharacterized biosynthetic gene cluster. Learn more on the JGI website.
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