The Berkeley Center for Structural Biology (BCSB) has operated five beamlines at the Advanced Light Source (ALS) for more than ten years, helping hundreds of crystallographers to determine the structures of more than 1,000 proteins. Two of the BCSB’s beamlines (8.2.1 and 8.2.2) are funded by the Howard Hughes Medical Institute (HHMI) to support the cutting edge research of structural biologists, including those in the HHMI research community.