Researchers in the Biological Systems and Engineering (BSE) Division are collaborating with colleagues at the Berkeley Lab Laser Accelerator (BELLA) Center to adapt the nascent technology of laser-driven ion accelerators to make a more effective type of radiation more readily available to patients. The mutually beneficial partnership gives BELLA scientists a real-world application around which to refine their experimental laser platform, and gives the biologists a chance to test how living tissue responds to laser-driven proton beams at FLASH dose rates.
Transferring Discoveries from Mouse Model to Humans
Scientists at Berkeley Lab are working to expand our understanding of breast cancer diagnosis and treatment. Recently, a group in the BSE Division developed a framework that enables the transfer of discoveries derived from mouse models to humans. This success will allow breast cancer researchers to better predict how likely a tumor in humans is to metastasize based on how the corresponding cells in mice behaved.
Trio of Recent Studies Underscore Harms of Exposure to Thirdhand Smoke
The thirdhand smoke (THS) research group in Biosciences’ Biological Systems and Engineering (BSE) Division contributed to three recently-published studies that further underscore the harms of exposure to the lingering toxic residues from tobacco smoke.
Scientists Explore Links Between Genetics, Gut Microbiome, and Memory
A team of researchers from two U.S. Department of Energy national laboratories has found new evidence of tangible connections between the gut and the brain. The team, led by Antoine Snijders at Berkeley Lab and Janet Jansson at Pacific Northwest National Laboratory (PNNL), identified lactate—a molecule produced by all species of one gut microbe—as a key memory-boosting molecular messenger. The work was published in the journal BMC Microbiome.
Microbiome Signature Could Predict Post-op Enterocolitis in Hirschsprung Disease Patients
Biosciences Area researchers, in collaboration with colleagues at Nanjing Medical University in China, performed the first study to prospectively investigate the gut microbiome in relation to Hirschsprung-associated enterocolitis (HAEC), a leading cause of death in Hirschsprung disease patients. They identified a microbiome signature that might predict the development of postoperative HAEC. In addition, they found that exclusive breastfeeding might reduce the risk of HAEC through modulation of the intestinal microbiome.
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