A team of researchers developed a high-throughput drug-discovery workflow leveraging time-resolved small-angle x-ray scattering (SAXS) capabilities at the Advanced Light Source’s (ALS) Structurally Integrated Biology for the Life Sciences (SIBYLS) beamline to identify small molecules capable of activating biomolecular dynamics associated with a desired therapeutic outcome.
Researchers Leverage SAXS to Understand Aspect of Microbial Metabolism
A team of Molecular Biophysics and Integrated Bioimaging Division researchers used synchrotron technology unique to the Advanced Light Source (ALS) at Berkeley Lab to probe the conformational states behind electron bifurcation.
Hura, Tsutakawa named Science Deputy, Structural Biology Department Head
Molecular Biophysics and Integrated Bioimaging (MBIB) Division Director Junko Yano has announced that staff scientists Greg Hura and Susan Tsutakawa have officially assumed the roles of MBIB Science Deputy and Head of the Structural Biology Department, respectively. They have been serving in these positions on an interim basis since August 2021.
Biosciences Researchers Launching Biopreparedness Projects
Two scientists in the Area, Greg Hura and Vivek Mutalik, are heading up research projects that are part of the Department of Energy’s Biopreparedness Research Virtual Environment (BRaVE) initiative. Yasuo Yoshikuni, a scientist at the Joint Genome Institute, is part of a third project that is being led by Brookhaven National Laboratory. These projects will leverage bioimaging expertise to develop better therapies and vaccines for viruses, develop a high-throughput platform to rapidly design countermeasures to drug-resistant pathogens, and unlock the molecular basis of plant-pathogen interactions to create resilient bioenergy crops.
Breaking Barriers in Drug Delivery with Better Lipid Nanoparticles
Berkeley Lab and Genentech are collaborating to make the next generation of lipid nanoparticles (LNPs), the drug delivery technology used in the COVID-19 vaccines. With their combined expertise in structural biology and pharmaceutical science, the team is designing LNPs that can precisely deliver vaccines and therapeutics to target tissues while improving the product’s shelf life and duration of action.
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