A first-of-its-kind study led by Cynthia McMurray and Aris Polyzos in the Molecular Biophysics and Integrated Bioimaging (MBIB) Division integrated cell type– and brain region–specific features of DNA repair in normal brains, setting a benchmark for the field. Their results, recently published in Nature Communications, suggest that DNA damage itself serves as the checkpoint, limiting the accumulation of genomic errors in cells during natural aging.
A New Genetic Hallmark for Predicting Breast Cancer Outcomes
Biosciences researchers have used Collaborative Cross mice, a mouse model system designed to mimic the diversity of human populations, to identify a set of genetic factors that could help refine treatment approaches for a fast-growing form of breast cancer.
Researchers Gain Mechanistic Insight into a Viral-factory Protein
A team that included Banumathi Sankaran of the Molecular Biophysics and Integrated Bioimaging Division studied a protein called σNS, an important component of some viral factories. Understanding how this protein works will foster development of therapeutic strategies against viruses that use similar proteins to replicate.
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