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blue DNA helix structures floating against a dark background An illustration in hues of purple, fuchsia, and cyan of DNA being transcribed into RNA to build a protein. Enhancers help activate this process. Harshi Munkundan (Credit: Los Alamos National Laboratory) Side by side colorized positron emission tomography images of two brains in coronal cross-section. Fluorescence microscopy image of breast cancer cells shows strong HER2 amplification in red. RX bottle with Metformin pills A complex of three proteins—SHOC2, PP1C, and RAS—plays a key role in signaling cells to replicate and is thus a potential target for anticancer drug development. Left: Cryo-electron microscopy (cryoEM) density map of the complex. Right: Ribbon structure showing the active site and a bound molecule (yellow) necessary for complex formation.

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