Using protein structures obtained in part at the Advanced Light Source (ALS), researchers from the University of California San Francisco (UCSF) produced simplified antibodies (“nanobodies”) engineered to be highly effective at blocking SARS-CoV-2, the virus that causes COVID-19. Because they are extremely stable, these nanobodies can be aerosolized, stored at room temperature, and self-administered as needed, directly to affected nasal or lung tissues using nasal sprays or inhalers.
Scientists Map Coronavirus Protein Linked to Immune Evasion, Disease Severity
A team of UC Berkeley and Berkeley Lab researchers used X-ray crystallography performed at the Advanced Light Source (ALS) to determine the atomic structure of ORF8, a protein secreted by the SARS-CoV-2 virus that is thought to help the pathogen evade and dampen response from human immune cells.
Experimental Drug Targets HIV in a Novel Way
Using Berkeley Center for Structural Biology (BCSB) beamline 5.0.1, researchers from Gilead Sciences investigated a promising small-molecule drug, GS‑6207, that they developed to inhibit replication of the human immunodeficiency virus (HIV).
Videos Showcase Biosciences’ Response to COVID-19
For the past several months, teams of bioscientists have utilized Berkeley Lab’s world-class research facilities to contribute to the national response to COVID-19, resulting in a wide range of promising research. Four videos showcase researcher contributions from across the Biosciences Area, which aim to help address some of the many scientific challenges posed by the pandemic.
Rotavirus VP3 Is a Multifunctional Capping Machine
Combining cryo-electron microscopy, biochemical assays, and protein crystallography at Advanced Light Source (ALS) Beamline 5.0.2 (part of the Berkeley Center for Structural Biology), researchers from the Baylor College of Medicine discovered that rotavirus VP3 incorporates in one place all the enzymatic activities required to effectively cap rotavirus mRNA, making it unique among viral-capping enzymes.
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