Biosciences researchers have used Collaborative Cross mice, a mouse model system designed to mimic the diversity of human populations, to identify a set of genetic factors that could help refine treatment approaches for a fast-growing form of breast cancer.
Biological Systems and Engineering Division Leadership Changes
Blake Simmons, Biological Systems and Engineering (BSE) Division Director, announced that Justin Heady has been named the BSE Deputy for Operations. In addition, Harshini Mukundun is assuming the role of Interim Department Head of the Bioengineering and Biomedical Sciences Department. Mukundun takes over from Antoine Snijders, who has led the department since 2016.
Infrared and AI Detect Low-dose Radiation Long After Exposure
Biosciences researchers have established a powerful new method that couples advanced infrared imaging techniques with statistical machine learning models to quickly and non-invasively determine with high accuracy whether an animal was exposed to radiation—even at extremely low doses almost three months post exposure.
Towards a New Framework for Radiation Cancer Treatment
Though it may seem counterintuitive, delivering ultrafast, high-intensity doses of radiation to tumors can actually reduce the toxicity to surrounding healthy cells, while still directing a potent anti-cancer effect towards the target. Scientists have documented this perplexing phenomenon—dubbed the FLASH radiotherapy effect—in both cell lines and animal models, but they have yet to confirm how or why it works. A new experimental platform that uses X-rays to investigate the FLASH effect brings science a step closer to clarifying its underlying mechanisms, laying the foundation for major strides in the field of radiation oncology.
Biosciences Area FY24 LDRD Projects
The projects of 21 Biosciences Area scientists and engineers received funding through the FY24 Laboratory Directed Research and Development (LDRD) program.
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