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Vivek Mutalik

Staff Scientist

Environmental Genomics and Systems Biology

  • Comparative and Functional Genomics

Secondary Affiliation: Biological Systems and Engineering

  • BioEngineering & BioMedical Sciences
  • Biodesign

Building: Aquatic Park Station 717 Potter St #180B, 977-0180B, CA 94710, Room 180B
Mail Stop: 977-180B
VKMutalik@lbl.gov

Programs & Initiatives

BIOFAB

Research Interests

  • Developing high-throughput functional discovery platform for thousands of microbial genes, phage genes and extending it to metagenomic samples  
  • Discovery of bacteriophage-host interaction determinants, mechanistic insights into antibiotic resistance and phage resistance, and how they impact host fitness
  • Approaches for doing esigned manipulation of microbial communities  
  • Engineering of phages, phage particles for diverse applications
  • Rational design of phage cocktails with antibiotics for phage therapy applications
  • Synthetic genetic parts for phylogenetically distinct and industrially important microbes and rules for their functional composition.

PRESS:

Cataloging Nature’s Hidden Arsenal: Viruses that Infect Bacteria

https://naturemicrobiologycommunity.nature.com/posts/a-tale-of-tailocins-bacterial-stabbing-tools

https://mammoth.bio/2020/10/28/mammoth-interviews-vivek-k-mutalik-phd-scientist-at-lbnl-and-co-founder-of-felix-biotechnology/

https://phage.directory/capsid/interview-vivek-mutalik

How Do You Fight Antibiotic Resistance? Ask a Virus.

Dub-seq Flagship Paper Published in Nature Communications

Dub-seq Wins 2017 R&D100 Award

Predictability: The Brass Ring For Synthetic Biology

Selected Publications
Selected Publications

LinkedIn Profile
ResearchGate Profile

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Biosciences Researchers Launching Biopreparedness Projects

September 18, 2023

Two scientists in the Area, Greg Hura and Vivek Mutalik, are heading up research projects that are part of the Department of Energy’s Biopreparedness Research Virtual Environment (BRaVE) initiative. Yasuo Yoshikuni, a scientist at the Joint Genome Institute, is part of a third project that is being led by Brookhaven National Laboratory. These projects will leverage bioimaging expertise to develop better therapies and vaccines for viruses, develop a high-throughput platform to rapidly design countermeasures to drug-resistant pathogens, and unlock the molecular basis of plant-pathogen interactions to create resilient bioenergy crops.

Dub-seq Used to Screen Phage Proteins for Antibiotic Properties

March 14, 2023

As conventional antibiotics continue to lose effectiveness against evolving pathogens, scientists are keen to employ the bacteria-killing techniques perfected by bacteriophages (phages), the viruses that infect bacteria. One major challenge is the difficulty of studying individual phage proteins and determining precisely how the virus wields these tools to kill their host bacteria. A team of researchers from Berkeley Lab, UC Berkeley, and Texas A&M University worked together on a high-throughput genetic screen to identify which part of the bacteria the phages were targeting.

Biosciences Area FY23 LDRD Projects

December 15, 2022

The projects of 22 Biosciences Area scientists and engineers received funding through the FY23 Laboratory Directed Research and Development (LDRD) program.

For more Vivek Mutalik news items »

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