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Asmit Bhowmick

Project Scientist

Molecular Biophysics and Integrated Bioimaging

  • Bioenergetics

Building: 33, Room 349
Mail Stop: 33R0345
abhowmick@lbl.gov

Research Interests

  • Unravelling the relationship between structure, dynamics and function of enzymes using
    • Time-resolved structural studies at X-ray free-electron lasers (XFEL)
    • Simulating biological systems using Molecular Dynamics/Quantum mechanical methods
  • X-ray crystallography data analysis – developing new methods for active sites of metalloenzymes
  • Current systems of interest include Photosystem II, a multi-subunit membrane enzyme catalyzing the water oxidation reaction.

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Researchers Capture Elusive Missing Step in Photosynthesis

May 5, 2023

After decades of effort, scientists have revealed atomic-scale details of the water splitting step of photosynthesis, the chemical process that generates the air we breathe. The latest work adds to our understanding of photosynthesis and will aid the development of fully renewable alternative energy sources.

Crystallography for the Misfit Crystals

January 19, 2022

Nicholas Sauter, a computer senior scientist in the Molecular Biophysics and Integrated Bioimaging (MBIB) Division, is co-leading a team working to provide a better way for scientists to study the structures of the many materials that don’t form tidy single crystals. Their new technique, called small-molecule serial femtosecond X-ray crystallography, or smSFX, supercharges traditional crystallography with the addition of custom-built image processing algorithms and an X-ray free electron laser (XFEL). In a paper published in Nature, the team demonstrated proof-of-principle for smSFX and reported the previously unknown structures of two metal-organic materials known as chacogenolates.

New Technique Gets the Drop On Enzyme Reactions

October 21, 2021

As part of an international collaboration, researchers at Lawrence Berkeley National Laboratory (Berkeley Lab), the Diamond Light Source synchrotron facility, and Oxford and Bristol Universities in England have developed a novel sample delivery system that expands the limited toolkit for performing dynamic structural biology studies of enzyme catalysis, which have so far mostly been limited to a small number of light-driven enzymes.

For more Asmit Bhowmick news items »

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