Biosciences News

What if checking the state of your arterial health were as simple as monitoring your blood pressure? New technology developed by Jonathan Maltz, a scientist in Berkeley Lab’s Molecular Biophysics and Integrated Bioimaging division, could make this a reality. Maltz came up with the idea of using sensors to detect the changes in the pulse pressure as blood flows through the brachial artery, a major vessel in the upper arm. Previous studies have shown a strong correlation between the health of brachial and coronary arteries. With initial funding from a Berkeley Lab Innovation Grant, Maltz developed an advanced prototype called the Engevity Cuff, which looks and feels much like a blood pressure monitor. He worked with UC San Francisco (UCSF) chief cardiologist Jeffrey Olgin and his team, who are conducting a major heart health study, to test the device on real patients. Last fall, startup company Lexington Biosciences licensed the technology to help further refine the device and bring it to the medical market.

Microbiomes are communities of microorganisms that live on and in people, plants, soil, oceans, and the atmosphere, playing important roles in each ecosystem. Today, the White House Office of Science and Technology Policy launched the National Microbiome Initiative, designed to advance the understanding of microbiome behavior and enable the protection of healthy microbiomes. With its Microbes to Biomes program, Berkeley Lab is well positioned to contribute. Both Mary Maxon, Principal Deputy for Biosciences, and Trent Northen, Interim Director of Environmental Genomics & Systems Biology, worked with Eoin Brodie of the Earth & Environmental Sciences Division and other leading scientists to co-author an mBio editorial that calls for a predictive understanding of Earth’s microbiomes to address 21st century challenges in the areas of energy, health, and environment. Read more at the Berkeley Lab News Center.

Working at temperatures near absolute zero, scientists at Berkeley Lab and UC Berkeley have captured images of proteins at work in the early steps of DNA transcription. Eva Nogales, a senior faculty scientist at in the Molecular Biophysics & Integrated Bioimaging Division, UC Berkeley professor of biochemistry and a Howard Hughes Medical Institute (HHMI) investigator, led the new study, published today in the journal Nature.

This latest research comes seven weeks after Nogales unveiled an earlier milestone using cryo-EM technology to image details of transcription factor TFIID in gene expression. Read the full UC Berkeley press release on the newest Nature paper.

Scientists at JBEI have engineered a strain of bacteria that enables a “one-pot” method for producing advanced biofuels from a slurry of pre-treated plant material. The achievement is a critical step in making biofuels a viable competitor to fossil fuels. Read more at the Berkeley Lab News Center.

Graham R. Fleming, senior scientist in the Molecular Biophysics & Integrated Bioimaging Division, has won the Royal Chemistry Society’s Faraday Lectureship Prize 2016. The prize was awarded for experimental and theoretical achievements that have redefined the study and understanding of fundamental chemical and photobiological processes in liquids, solutions and proteins. A particular emphasis in Fleming’s research is photosynthetic light harvesting and its regulation via nonphotochemical quenching.