For Normal Heart Function, Look Beyond the Genes
Researchers have shown that when parts of a genome known as enhancers are missing, the heart works abnormally, a finding that bolsters the importance of DNA segments once considered “junk” because they do not code for specific proteins. The study, led by Environmental Genomics & Systems Biology (EGSB) Division scientists Diane Dickel, Axel Visel and Len Pennacchio, appears in the journal Nature Communications. The team included other members of EGSB’s Mammalian Functional Genomics Laboratory and collaborators from the Ludwig Institute for Cancer Research and UC San Diego.
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