Researchers at Berkeley Lab and Michigan State University (MSU), led by Cheryl Kerfeld, have created a genetically engineered bacterial microcompartment (BMC) shell based on natural structures and the principles of protein evolution. The new shell is smaller and simpler, made of only a single designed protein (natural BMCs are made of up to three), making it easier to work with in the lab.
Pam Ronald Elected to National Academy of Sciences
Pam Ronald, faculty scientist in EGSB and scientific lead of plant pathology at the Joint BioEnergy Institute (JBEI), was elected to the National Academy of Sciences in recognition of her distinguished and continuing achievements in original research. She joins 100 scientists and engineers from the U.S. and 25 from across the world as new lifelong members and foreign associates.
Antibody Uses Mimicry to Block SARS Coronavirus
To better understand how coronavirus antibodies work, a team of researchers at the University of Washington studied spike protein structures in complex with neutralizing antibody fragments isolated from SARS and MERS survivors. To visualize how the spike structures interact with the antibody fragments, they used a cryo-electron microscopy (cryo-EM) for the spikes, which are resistant to crystallization, and protein crystallography for the fragments. The high-resolution x-ray crystallography was performed at the Advanced Light Source (ALS) Beamline 5.0.1, part of the Berkeley Center for Structural Biology (BCSB).
BCSB Helps Characterize New Arsenic-based Antibiotic
A newly-discovered arsenic-containing compound produced by a soil bacterium shows promise as a broad-spectrum antibiotic. In a paper published in the Nature journal Communications Biology, an international team of researchers demonstrated that arsinothricin (AST) is effective against many types of gram-negative and gram-positive bacteria. The effort was led by Barry Rosen of the Florida International University College of Medicine and Masafumi Yoshinaga of the National Agriculture and Food Research Organization (NARO) in Japan. Banumathi Sankaran, a research scientist in the Berkeley Center for Structural Biology (BSCB) at the Advanced Light Source (ALS), was an author on the paper.
New Round of Funding for Thirdhand Smoke Research
Berkeley Lab thirdhand smoke researchers have been awarded a new three-year grant totaling $904,744. The funding from the Tobacco-Related Disease Research Program (TRDRP) will support translational studies aimed at mitigating health impacts of exposure to thirdhand smoke (THS)—the toxic residues from tobacco smoke that linger on indoor surfaces and in dust long after a cigarette has been extinguished. From the Biosciences Area, Biological Systems and Engineering (BSE) Division staff scientist Bo Hang will serve as principal investigator on the studies, with senior scientist Jian-Hua Mao and staff scientist Antoine Snijders, also of BSE, as co-investigators. Collaborators on the project include staff scientist Hugo Destaillats and retiree affiliate Lara Gundel in the Energy Technologies Area (ETA) at Berkeley Lab, as well as researchers at California Consortium on Thirdhand Smoke partner institutions UC San Francisco and UC Riverside.
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