Blake Simmons, Biological Systems and Engineering (BSE) Division Director, announced that Justin Heady has been named the BSE Deputy for Operations. In addition, Harshini Mukundun is assuming the role of Interim Department Head of the Bioengineering and Biomedical Sciences Department. Mukundun takes over from Antoine Snijders, who has led the department since 2016.
A Better Understanding of DNA Unpacking
Using specialized equipment, including high-resolution cryo-EM researchers were able to study the atomic structure of a complex that allows enzymes to access DNA.
Time-Resolved SAXS Screen of Small-Molecule Drug Candidates
A team of researchers developed a high-throughput drug-discovery workflow leveraging time-resolved small-angle x-ray scattering (SAXS) capabilities at the Advanced Light Source’s (ALS) Structurally Integrated Biology for the Life Sciences (SIBYLS) beamline to identify small molecules capable of activating biomolecular dynamics associated with a desired therapeutic outcome.
Young Biosciences Researchers Rub Elbows with Nobel Company
Margaret Doyle, a graduate student in the Molecular Biophysics and Integrated Bioimaging (MBIB) Division’s YYK group, and Christian Patrick Nikolaus Tanner, a graduate student with MBIB faculty scientist Naomi Ginsberg, were among the 27 young scientists selected to represent the University of California as a UC President Lindau Nobel Laureate Meeting Fellow at the recent gathering in Germany.
Structural Biology Brings Chemotherapy Resistance Into High Resolution
Biosciences researchers conducted the first ever structural analysis of a key protein involved in DNA damage repair and cancer. While the narrative around cancer chemotherapy has historically focused on DNA damage repair pathways, findings from this study underscore the role of RNA-mediated processes on chemotherapy response, which could have major implications for cancer treatment outcomes.
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