A team led by CRISPR pioneer Jennifer Doudna and her longtime collaborator Jill Banfield has developed a clever tool to edit the genomes of bacteria-infecting viruses called bacteriophages using a rare form of CRISPR. The ability to easily engineer custom-designed phages—which has long eluded the research community—could help researchers control microbiomes without antibiotics or harsh chemicals, and treat dangerous drug-resistant infections. A paper describing the work was recently published in Nature Microbiology.
Metformin May Mitigate More Severe COVID-19 Outcomes in Patients with Prediabetes, PCOS
An international team led by Justin Reese, a research scientist in the Environmental Genomics and Systems Biology (EGSB) Division, analyzed electronic health record data aggregated in the National COVID Cohort Collaborative (N3C) Data Enclave to assess whether metformin is associated with reduced COVID-19 severity in people with prediabetes or polycystic ovary syndrome (PCOS), two common conditions that increase the risk of severe COVID-19 presentation.
The JGI’s Genomes OnLine Database Celebrates 25 Years of Data Contextualization
Since its launch 25 years ago, the Genomes OnLine Database has matured from six projects on a spreadsheet into a flagship genomic metadata repository, making curated microbiome metadata that follows community standards freely available, and enabling large-scale comparative genomics analysis initiatives.
JGI Researchers Provide a Perspective on Giant Virus Diversity
In the last thirty years, in environments all over the world, scientists have discovered giants among viruses. Culturing studies have been key to understanding these viruses’ host range, morphological structures, and infection strategies. More recently, researchers have employed cultivation-independent approaches to discover thousands of new giant viruses, rapidly expanding the diversity of the Nucleocytoviricota phylum. A new review provides a perspective on giant virus diversity, and how sequencing and bioinformatics have sped up the study of giant viruses.
Biosciences Inventor Deepika Awasthi Wins 2022 Berkeley Lab Pitch Competition
Biosciences Area scientist Deepika Awasthi won the 2022 Berkeley Lab Pitch Competition held on October 27. The competition, funded by the Department of Energy (DOE) and co-hosted by the Intellectual Property Office and the Haas School of Business, was designed to provide scientist-entrepreneurs at the Lab with experience in pitching to key stakeholders such as potential investors and partners.
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