PARP1 is an enzyme that senses DNA damage and sends a cellular signal to carry out repair. It has been found to be upregulated in several carcinomas and inhibiting its activity has been shown to repress tumor growth and metastasis. PARP1 has also emerged as a promising therapeutic target for Alzheimer and Parkinson diseases, where attenuating the enzyme’s hyperactivity can help cells survive. To better understand the regions of PARP1 that various inhibitors attack, an international team of researchers captured the first snapshot of the enzyme in the active state it adopts after detecting DNA damage.
Advances in cryogenic electron microscopy have enabled an international team of experts to visualize the structure of a cyanobacterial phycobilisome with nearly atomic resolution. The work, a collaboration among researchers at Michigan State University, UC Berkeley, Berkeley Lab, and the University of South Bohemia in the Czech Republic, was published in Nature. Knowing the position of different proteins and pigments helps scientist better understand this natural process and can inspire future applications in areas such as renewable energy and environmental remediation.
The supply of a plant-derived anti-cancer drug can finally meet global demand after a team of scientists from Denmark and the U.S. engineered yeast to produce the precursor molecules, which could previously only be obtained in trace concentrations in the native plant. A study describing the breakthrough was recently published in Nature. The international team included four researchers from the Biological Systems and Engineering Division: Leanne Jade G. Chan, Edward Baidoo, Christopher J. Petzold, and Jay D. Keasling.
A new paper from Biosciences researchers in the Environmental Genomics and Systems Biology Division, the Molecular Biophysics and Integrated Bioimaging Division, and the Joint BioEnergy Institute (JBEI) reveals the possibility that many of the proteins we thought we knew actually exist in other, unknown shapes.
Seven innovative technologies from Berkeley Lab have been honored with a 2022 R&D 100 Award. Biosciences Area researchers contributed to two different products that were awarded.