JBEI Research Scientist, Ee-Been Goh was featured in an article by Laboratory Equipment to talk about what she is working on, whom she is mentoring and her take on what it’s like to be a female in the male-dominated science space. Read more
Ignacio Tinoco’s 59 Years in Chemistry Profiled
Ignacio Tinoco, Jr., an affiliate in the Molecular Biophysics & Integrated Bioimaging Divsion, has been a pioneer in many fields, but he is most known for his invaluable contribution to the study of RNA folding. He has taught in UC Berkeley’s chemistry department for 59 years. When he first started on the faculty, he was advised by the dean to wear a tie so that he could be distinguished from the students. Read more in the Berkeley Science Review.
New Technologies Fuel Cryo-EM’s Renaissance
In a pair of breakthrough Nature papers published recently, researchers in Eva Nogales’ Lab at UC Berkeley and Berkeley Lab (Molecular Biophysics & Integrated Bioimaging Division) mapped two important protein functions in unprecedented detail: the role of TFIID, effectively improving our understanding of how our molecular machinery identifies the right DNA to copy; and how proteins unzip double-stranded DNA, which gives us insights into the first-key steps in gene activation.
These papers are representative of the renaissance currently under way in the cryo-electron microscopy (cryo-EM) field—driven primarily by the rise of cutting-edge electron detector cameras, sophisticated image processing software and access to NERSC supercomputing resources. Read the full story, written by Linda Vu of NERSC.
DOE JGI Team Helps Develop Novel Techniques to Visualize Uncultured Microbial Cell Activity
“One of the biggest problems in the exploration of microbial dark matter is that so far, it is very complicated to determine when uncultured microbes are metabolically active and what their ecological function in a system is.”
In a study published online June 28, 2016 in the Proceedings of the National Academy of Sciences (PNAS), researchers at the California Institute of Technology (Caltech) and the U.S. Department of Energy Joint Genome Institute (DOE JGI), a DOE Office of Science User Facility, utilized a recently refined technique to identify both individual active cells, and single clusters of active bacteria and archaea within microbial communities. Understanding the true scope of the planet’s microbial diversity is of interest to the DOE in order to learn how they can be harnessed for a wide range of energy and environmental challenges. Read more on the DOE JGI website.
Auer to Head Cellular and Tissue Imaging
Manfred Auer, Staff Scientist and Director of Physical Analysis at the Joint BioEnergy Institute, has agreed to serve as the Head of Cellular and Tissue Imaging Department in the Molecular Biophysics & Integrated Bioimaging Division. Auer has been with Berkeley Lab since 2004, studying inner ear molecular machines, molecular mechanisms in cancer malignancy, biofilms, and bioenergy, as well as developing new imaging methods. He will succeed Bill Moses, who retired on June 29, after 36 years at Berkeley Lab. Moses’ research focused on advanced instrumentation for nuclear medical imaging, including Positron Emission Tomography (PET), which he also applied to the area of environmental bioremediation.
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