N. Louise Glass, director of the Environmental Genomics and Systems Biology Division, is being named a fellow of the Mycological Society of America (MSA) at their annual meeting being held this week in Athens, GA. MSA Fellows recognize mid-career members and also MSA volunteers. Glass is being honored as an outstanding mycologist who has served the MSA in several capacities, including as a member of both the Society’s leadership body and the Editorial Board of Mycologia, the official journal of the MSA. Read more in the MSA meeting announcement.
DOE Renews Funding for Joint BioEnergy Institute at Berkeley Lab
The Department of Energy’s Joint BioEnergy Institute (JBEI), led by Berkeley Lab, is one of four DOE Bioenergy Research Centers to receive funding in support of innovative research on biofuels and bioproducts. The four centers will receive a total of $40 million. The award marks the next research phase at JBEI, originally established in 2007. Read more in the Berkeley Lab News Center.
Epigenetic Effects of ‘Genomic Parasites’ Impact Their Evolution
In a study published in eLife, Biological Systems and Engineering (BSE) postdoctoral researcher Grace Lee and senior scientist Gary Karpen investigated the extent to which transposons—bits of DNA that copy themselves and jump to other locations in the genome—harm organisms through epigenetic means, such as changing the way DNA is packaged in cells, and whether this influences how transposons evolve. In a Q&A with the journal, Lee explained the background of the research, the specific question she and Karpen were interested in, and the most illuminating result among their findings.
New Algorithms Extract Biological Structure from Limited Data
A cross-disciplinary effort by Berkeley Lab scientists has yielded a new algorithmic approach for determining 3D molecular structures from single-particle X-ray free-electron laser (XFEL) imaging. Peter Zwart of the Molecular Biophysics & Integrated Bioimaging Division (MBIB) worked with James Sethian and Jeffrey Donatelli of the Computational Research Division’s Mathematics Group to create the multi-tiered iterative phasing (M-TIP) framework, which uses advanced mathematical techniques to extract nano-scale biological structures from sparse and noisy diffraction data. A paper detailing the approach was published in the Proceedings of the National Academy of Sciences.
DOE JGI Helps Develop New Technology to Access Microbial Dark Matter
Miniaturized, microfluidic-based metagenomics technology developed under the aegis of U.S. Department of Energy Joint Genome Institute’s (DOE JGI’s) Emerging Technology Opportunity Program (ETOP) has enabled researchers to shine a light on so-called microbial “dark matter”—the majority of the planet’s microbial diversity that remains uncultivated. Researchers from Stanford University demonstrated the efficacy of the new technique, extracting 29 novel microbial genomes from Yellowstone hot spring samples while still preserving single-cell resolution to enable accurate analysis of genome function and abundance. Read more in this JGI Science Highlight.
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