Two proposals, from Biosciences Area researchers Cynthia McMurray and Carolyn Larabell, have been recommended for funding by the Chan Zuckerberg Initiative (CZI) through a new grant program focused on developing collaborative computational tools to support the Human Cell Atlas (HCA). A global endeavor governed by an organizing committee co-chaired by Aviv Regev at the Broad Institute of MIT and Harvard and Sarah Teichmann at the Wellcome Trust Sanger Institute, the HCA will generate a variety of molecular and imaging data across a range of modalities and spatial scales. To advance the analysis, interpretation, and dissemination of these data, the CZI issued an open call in July 2017 for proposals aimed at creating new computational tools, algorithms, visualizations, and benchmark datasets. After a thorough evaluation process, CZI recommended 85 projects (out of nearly 300 submissions) for funding, and will provide $15 million in total over one year for their execution.
Maxon Co-authors Editorial on State S&T Policy Fellows Program
Associate Laboratory Director for Biosciences Mary Maxon and Bruce Alberts, the chancellor’s leadership chair for science and education in the Department of Biochemistry and Biophysics at the University of California, San Francisco, co-wrote an editorial on “Science for State Legislatures” published this week in Science. In it, they make the case that state Science and Technology (S&T) Policy Fellowship programs, such as the nearly decade-old program in California’s state legislature (on whose advisory committee both serve), are a critical bridge between the scientific community and the government. Among other contributions, fellows help policymakers understand “science as a second language.” California’s program is itself modeled on the national American Association for the Advancement of Science (AAAS) S&T Policy Fellowship Program, which over 45 years has enabled thousands of PhD scientists, engineers, and physicians to work for a year for the U.S. government. Alberts and Maxon believe that “the establishment of S&T fellowship programs in other states could greatly increase evidence-based policy-making and not only benefit state policy-makers but also help to inform national policy-making and society as a whole.”
A Core−Shell Nanotube Array for Artificial Photosynthesis
“The key design principle of natural photosynthesis is the closing of the photosynthetic cycle on the shortest possible length scale under membrane separation of the incompatible water oxidation and proton reduction environments,” said Heinz Frei, a senior scientist in Biosciences’ Molecular Biophysics and Integrated Bioimaging (MBIB) Division. With collaborators Eran Edri, a former postdoctoral fellow in MBIB now at Ben-Gurion University, and Shaul Aloni in the Molecular Foundry Division, Frei developed a fabrication method to make a square-inch sized artificial photosystem, in the form of an inorganic core-shell nanotube array, that implements this design principle for the first time. The method was described in a paper published earlier this year in ACS Nano.
Northen Lab Publishes Video Protocol for Building EcoFABs
Scientists in Trent Northen’s groups in Environmental Genomics and Systems Biology (EGSB) and Metabolomics Technology at the DOE Joint Genome Institute (JGI) have published detailed video protocols for creating fabricated ecosystems, or EcoFABs, in the Journal of Visualized Experiments (JOVE). These laboratory-scale controlled habitats, constructed using widely available 3D printing technologies, enable mechanistic studies of plant-microbe interactions within specific environmental conditions. The published protocols serve as a starting point for other researchers, ideally helping to create standardized experimental systems for investigating plant-microbe interactions. The video component of this article can be found here.
Computing Sciences and Biosciences Hold Machine Learning Workshop
The Lab’s Computing Sciences and Biosciences Areas jointly held a week-long workshop focused on machine learning in data science, the goal of which was to build bridges through a common foundation in statistical computing. Thirty attendees from Biosciences, Computing Sciences, and Lab IT received hands-on training provided by Data Incubator before engaging in a “hackathon” to apply the techniques to relevant science problems and data sets.
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