A team of researchers developed a high-throughput drug-discovery workflow leveraging time-resolved small-angle x-ray scattering (SAXS) capabilities at the Advanced Light Source’s (ALS) Structurally Integrated Biology for the Life Sciences (SIBYLS) beamline to identify small molecules capable of activating biomolecular dynamics associated with a desired therapeutic outcome.
Structural Biology Brings Chemotherapy Resistance Into High Resolution
Biosciences researchers conducted the first ever structural analysis of a key protein involved in DNA damage repair and cancer. While the narrative around cancer chemotherapy has historically focused on DNA damage repair pathways, findings from this study underscore the role of RNA-mediated processes on chemotherapy response, which could have major implications for cancer treatment outcomes.
Researchers Leverage SAXS to Understand Aspect of Microbial Metabolism
A team of Molecular Biophysics and Integrated Bioimaging Division researchers used synchrotron technology unique to the Advanced Light Source (ALS) at Berkeley Lab to probe the conformational states behind electron bifurcation.
How X-rays Could Make Reliable, Rapid COVID-19 Tests a Reality
An imaging technique pioneered by Berkeley Lab is helping reveal the best antibodies to test for in rapid and reliable COVID-19 detection. Although current tests such as polymerase chain reaction (PCR) are highly accurate, these samples must be sent to an accredited lab for testing, causing a longer wait time for results. Michal Hammel, a research scientist in the Molecular Biophysics and Integrated Bioimaging Division, and Curtis D. Hodge led a study that could help get reliable, self-administered tests with instant results on the market.
Study Finds ‘Missing Link’ in the Evolutionary History of Carbon-Fixing Protein Rubisco
In a study appearing in Nature Plants, researchers from UC Davis, UC Berkeley, and Berkeley Lab report the discovery and characterization of a previously undescribed lineage of form I rubisco – one that the researchers suspect diverged from form I rubisco prior to the evolution of cyanobacteria. The novel lineage, called form I’ rubisco, gives researchers new insights into the structural evolution of form I rubisco, potentially providing clues as to how this enzyme changed the planet.
The work was led by Patrick Shih, a UC Davis assistant professor and the director of Plant Biosystems Design at the Joint BioEnergy Institute (JBEI), and Doug Banda, a postdoctoral scholar in his lab.
Was this page useful?
Send
