In Cell Genomics, an international consortium led by researchers at the Joint Genome Institute team generated 824 new Actinobacteria genomes, which were were combined with nearly 5,000 publicly available ones and 1,100 metagenome-assembled genomes (MAGs) reconstructed from sequenced environmental samples in a previous study.
Using RIViT-seq technology, which combines an in vitro transcription assay with RNA sequencing, researchers identified the target genes of 11 sigma factors in Streptomyces coelicolor. The work, published in Nature Communications, was conducted by Joint Genome Institute (JGI) Director Nigel Mouncey and research scientist Hiroshi Otani. Both are members of the JGI’s Secondary Metabolite Science Program, which Mouncey leads. Transcription factors control when and how genes are turned on or off, making transcriptional regulation critical as it ensures those genes vital for growth and survival across various environments are expressed when their functions are needed. Learn more on the JGI website.
In Science, a team led by Jean-Marie Volland, a scientist with joint appointments at the DOE Joint Genome Institute (JGI) and the Laboratory for Research in Complex Systems, and Silvina Gonzalez-Rizzo and Olivier Gros of the Université des Antilles, described the morphological and genomic features of a giant filamentous bacterium, along with its life cycle.
Recently reported in Nature Communications, researchers led by Hal Alper at The University of Texas at Austin and Michael Jewett of Northwestern University describe a two-pronged approach that starts with engineered yeast cells but then moves out of the cell structure into a cell-free system. The work complements efforts to further develop sustainable alternative approaches for manufacturing bioproducts and biofuels. This is the first report of their work supported through the JGI’s Emerging Technologies Opportunity Program. Read the full story here on the JGI website.
On May 25, Berkeley Lab and Biosciences Area leadership officially welcomed the EcoPOD to its home at Potter Street in West Berkeley. The Lab’s Deputy Director for Research Horst Simon and Associate Laboratory Director for Biosciences Mary Maxon opened the doors of the EcoPOD after Maxon cut the ceremonial ribbon.