The Chan Zuckerberg Biohub Investigator Program recently awarded $21 million to 21 University of California, Berkeley researchers. Of this group, four are faculty scientists in the Biosciences Area.
All-star Scientific Team Seeks to Edit Entire Microbiomes with CRISPR
CRISPR enzymes are like super scissors: they cut, delete, and add genes to a specific kind of cell, one at a time. But now, UC Berkeley faculty and Biosciences Area researchers have figured out how to add or modify genes within a microbial community of many different species, coining the phrase, “community editing.”
New Device Advances Commercial Viability of Solar Fuels
A research team led by Francesca Toma, a staff scientist in the Liquid Sunlight Alliance (LiSA) and Chemical Sciences Division (CSD), has developed an artificial photosynthesis device with remarkable stability and longevity as it converts sunlight and carbon dioxide into ethylene and hydrogen—two promising sources of renewable fuels. The team used electron microscopy at the Molecular Foundry and ambient pressure X-ray photoelectron spectroscopy (APXPS) at the Advanced Light Source to reveal how the device degrades with use, then demonstrate how to mitigate those processes.
Chloro-phylling in the Answers to Big Questions
A team of scientists, including many in the Molecular Biophysics and Integrated Bioimaging Division, uncovered new details about the reaction that powers photosynthesis. Understanding this reaction could lead to world-changing advances in technology, medicine, or energy––and also gives insight into how the enzyme photosystem II produces the oxygen we breathe. Their latest work was recently published in Nature Communications and two of the authors, Vittal Yachandra and Philipp Simon, spoke with Strategic Communications about that, shooting stuff with lasers, and why they chose this field of research.
Structure of Human SAGA Protein Complex Solved
A team led by Eva Nogales, senior faculty scientist in the Molecular Biophysics and Integrated Bioimaging (MBIB) Division, has produced the first detailed 3D structure of human SAGA, a 20-piece molecular machine that’s crucial to life. The structure, reported in Nature Structural & Molecular Biology, revealed some unexpected differences between the human and yeast versions of SAGA and could guide the development of drugs to treat diseases that arise when this complex malfunctions.
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