Biochemist Jennifer Doudna, a faculty scientist in the Molecular Biophysics and Integrated Bioimaging (MBIB) Division, founder of the Innovative Genomics Institute, and a professor at UC Berkeley, has received the National Medal of Technology and Innovation, the nation’s highest honor for technological achievement. Doudna, who is also a Howard Hughes Medical Institute investigator, was honored for her work developing the CRISPR-Cas9 gene-editing technology.
How to Edit the Genes of Nature’s Master Manipulators
A team led by CRISPR pioneer Jennifer Doudna and her longtime collaborator Jill Banfield has developed a clever tool to edit the genomes of bacteria-infecting viruses called bacteriophages using a rare form of CRISPR. The ability to easily engineer custom-designed phages—which has long eluded the research community—could help researchers control microbiomes without antibiotics or harsh chemicals, and treat dangerous drug-resistant infections. A paper describing the work was recently published in Nature Microbiology.
All-star Scientific Team Seeks to Edit Entire Microbiomes with CRISPR
CRISPR enzymes are like super scissors: they cut, delete, and add genes to a specific kind of cell, one at a time. But now, UC Berkeley faculty and Biosciences Area researchers have figured out how to add or modify genes within a microbial community of many different species, coining the phrase, “community editing.”
CRISPR Voted Top Breakthrough at Berkeley Lab
In celebration of the Lab’s 90th anniversary, 16 of our most popular “90 Breakthroughs” faced off in the first ever Berkeley Lab Breakthroughs Bracket Challenge on Twitter. After four weeks of public voting online, the top breakthrough was “Created a Powerful Gene Editing Tool”—otherwise known as CRISPR!
Jennifer Doudna and the Nobel Prize: The Advanced Light Source Perspective
Emmanuelle Charpentier and Jennifer Doudna winning the 2020 Nobel Prize for Chemistry for their development of the CRISPR method of genome editing is a momentous achievement, supported by the contributions of numerous individuals and institutions, including the Advanced Light Source (ALS) synchrotron user facility at Berkeley Lab. This feature details how Doudna’s research was enabled by the facility’s early embrace of hard X-ray crystallography technology for atomic-level understanding of molecular structure, as well as her use of the Berkeley Center for Structural Biology’s (BCSB’s) wiggler-based beamline 5.0.2 for macromolecular crystallography. Doudna has published some 35 papers using ALS crystallography beamlines, including two cited by the Nobel Committee in its CRISPR-Cas9 scientific background document.
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