A team of Molecular Biophysics and Integrated Bioimaging Division researchers used synchrotron technology unique to the Advanced Light Source (ALS) at Berkeley Lab to probe the conformational states behind electron bifurcation.
Researchers in the Berkeley Synchrotron Infrared Structural Biology (BSISB) Imaging Program developed a technique that combines a novel microfluidic device and infrared spectroscopy to study how a cellulose-degrading enzyme works in real time.
Molecular Biophysics and Integrated Bioimaging (MBIB) Division Director Junko Yano has announced that staff scientists Greg Hura and Susan Tsutakawa have officially assumed the roles of MBIB Science Deputy and Head of the Structural Biology Department, respectively. They have been serving in these positions on an interim basis since August 2021.
Two scientists in the Area, Greg Hura and Vivek Mutalik, are heading up research projects that are part of the Department of Energy’s Biopreparedness Research Virtual Environment (BRaVE) initiative. Yasuo Yoshikuni, a scientist at the Joint Genome Institute, is part of a third project that is being led by Brookhaven National Laboratory. These projects will leverage bioimaging expertise to develop better therapies and vaccines for viruses, develop a high-throughput platform to rapidly design countermeasures to drug-resistant pathogens, and unlock the molecular basis of plant-pathogen interactions to create resilient bioenergy crops.
The SIBYLS beamline at the Advanced Light Source was used to characterize proteins dreamt up by a reinforcement learning algorithm. The algorithm, developed by researchers in David Baker’s lab at the University of Washington, is powered by the machine learning strategy behind computer programs capable of defeating top human players at board games like chess and go. The advance could create a pathway to greater control when designing therapeutic proteins, vaccines, and other molecules.