Yasuo Yoshikuni

Biologist Staff Scientist

DOE Joint Genome Institute

Science Programs

Secondary Affiliation: Environmental Genomics and Systems Biology

Molecular EcoSystems Biology

Biological Systems and Engineering

BioEngineering & BioMedical Sciences
Biodesign

YYoshikuni@lbl.gov

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JGI Adds Actinobacteria Chapter in the Genomic Encyclopedia of Bacteria and Archaea

November 11, 2022

In Cell Genomics, an international consortium led by researchers at the Joint Genome Institute team generated 824 new Actinobacteria genomes, which were were combined with nearly 5,000 publicly available ones and 1,100 metagenome-assembled genomes (MAGs) reconstructed from sequenced environmental samples in a previous study.

Bioscientists to Receive DOE Funding for Biomanufacturing and Microbiome Research

September 30, 2022

Biosciences researchers are among the recipients of four new DOE awards. Two awards will focus on reducing carbon emissions while producing bioenergy. The other two are aimed at understanding the role of microbiomes in the biogeochemical cycling of elements like carbon.

JGI Extracts the Secrets of Secondary Metabolites

August 23, 2022

Microbial secondary metabolites, those molecules not essential for growth yet essential for survival, may now be easier to characterize following a JGI proof-of-concept study in which researchers paired CRISPR and CRAGE technologies. CRAGE (developed by a JGI team led by Yasuo Yoshikuni) offers CRISPR a point of entry into microbes that it previously lacked. Then, by using CRISPR to knock out or activate genes, researchers at the JGI were able to monitor loss- and gain-of-function, with the analytical data showing peaks and valleys in secondary metabolites as genes are edited. The pairing proved to rapidly confirm enhanced production of 22 metabolites from six biosynthetic gene clusters. One of those was a metabolite from a previously uncharacterized biosynthetic gene cluster. Learn more on the JGI website.

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